The use of orthobiologics, natural substances derived from the body intended for accelerated repair and regeneration of injured tendons, ligaments, muscles or bones, has increased over the last several years. Platelet-Rich Plasma (PRP) is a type of orthobiologic that has been used to manage knee osteoarthritis (OA) for more than a decade.
Over the past several decades rates of obesity and diabetes in the United States have been rising. In 2015 the Centers for Disease Control estimated that 30.3 million Americans were living with diabetes, a figure representing 9.5% of the population.
Osteoarthritis of the knee is the most common cause of chronic knee pain and affects an estimated 14 million people in the United States. Total knee replacement is the ultimate procedure for the treatment of late-stage osteoarthritis of the knee.